The Dissociation of Pentameric to Monomeric C-Reactive Protein Localizes and Aggravates Inflammation: In vivo Proof of a Powerful Pro-Inflammatory Mechanism and a New Anti-Inflammatory Strategy

B Ba Bake k r ID ID DI I I He Hear art t an and d Di Diab a et etes es I Ins nsti titu tute te, , Me Melb lbou ou our rne, , V Vic icto t ri ia, a, a, A A Aus ustr tral alia i ; 3 De Dept pt p o of f Me Medi dicine ne, Im m mpe p rial Col lle lege ge ge L Lo on nd do don, n L L Lon ondo do on n, n, U U Un n nited d d K K King g gd do om; m; ; Abstract Background—The relevance of the dissociation of circulating pentameric C-reactive protein